Article
A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.
Human molecular genetics - 1 Jul 2011
Lanson Nicholas A, Maltare Astha, King Hanna, Smith Rebecca, Kim Ji Han, Taylor J Paul, Lloyd Thomas E, Pandey Udai Bhan
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder characterized by the loss of motor neurons. Fused in sarcoma/translated in liposarcoma (FUS/TLS) and TAR DNA-binding protein (TDP)-43 are DNA/RNA-binding proteins found to be mutated in sporadic and familial forms of ALS. Ectopic expression of human ALS-causing FUS/TLS mutations in Drosophila caused an accumulation of ubiquitinated...
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