Article
The impact of age and number of mutations on the size of clonal hematopoiesis.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2024
Wang Kai, Zhang Wen, Yi Li, Zhao Ming, Li Peng-Yu, Fu Mei-Hong, Lin Rong, Zhu Yong-Mei, Li Jian-Feng, Yang Wei-Ping, Fang Hai, Chen Zhu, Cai Wang-Wei, Ren Rui-Bao
Abstract excerpt
Clonal hematopoiesis (CH) represents the clonal expansion of hematopoietic stem cells and their progeny driven by somatic mutations. Accurate risk assessment of CH is critical for disease prevention and clinical decision-making. The size of CH has been showed to associate with higher disease risk, yet, factors influencing the size of CH are unknown. In addition, the characteristics of CH in long-lived individuals...
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