Article
A sheep pangenome reveals the spectrum of structural variations and their effects on tail phenotypes.
Genome research - 1 Mar 2023
Li Ran, Gong Mian, Zhang Xinmiao, Wang Fei, Liu Zhenyu, Zhang Lei, Yang Qimeng, Xu Yuan, Xu Mengsi, Zhang Huanhuan, Zhang Yunfeng, Dai Xuelei, Gao Yuanpeng, Zhang Zhuangbiao, Fang Wenwen, Yang Yuta, Fu Weiwei, Cao Chunna, Yang Peng, Ghanatsaman Zeinab Amiri, Negari Niloufar Jafarpour, Nanaei Hojjat Asadollahpour, Yue Xiangpeng, Song Yuxuan, Lan Xianyong, Deng Weidong, Wang Xihong, Pan Chuanying, Xiang Ruidong, Ibeagha-Awemu Eveline M, Heslop-Harrison Pat J S, Rosen Benjamin D, Lenstra Johannes A, Gan Shangquan, Jiang Yu
Abstract excerpt
Structural variations (SVs) are a major contributor to genetic diversity and phenotypic variations, but their prevalence and functions in domestic animals are largely unexplored. Here we generated high-quality genome assemblies for 15 individuals from genetically diverse sheep breeds using Pacific Biosciences (PacBio) high-fidelity sequencing, discovering 130.3 Mb nonreference sequences, from which 588 genes were...
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