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Article

Molecular QTL are enriched for structural variants in a cattle long-read cohort.

Communications biology - 21 Jan 2026

Mapel Xena Marie, Leonard Alexander S, Pausch Hubert

Abstract excerpt

Sequencing cohorts with long-read technology is crucial to understand the impact of structural variants (SVs) on complex traits. Here, we obtain 4.86 terabases of HiFi reads with an average read N50 of 16.3 Kb from 120 Bos taurus taurus bulls, yielding a mean coverage depth of 13.5-fold. We genotype 23.8 M small variants (SNPs and short INDELs) and 79.3 k SVs to perform association testing with molecular...

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Cattle
Genomic Structural Variation
Genotype
Phenotype
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantitative Trait Loci

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PMID: 41565764
DOI: 10.1038/s42003-026-09596-w
PMCID: PMC12923665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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