Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional impact of splicing variants in the elaboration of complex traits in cattle.

Nature communications - 24 Apr 2025

Charles Mathieu, Gaiani Nicolas, Sanchez Marie-Pierre, Boussaha Mekki, Hozé Chris, Boichard Didier, Rocha Dominique, Boulling Arnaud

Abstract excerpt

GWAS conducted directly on imputed whole genome sequence have led to the identification of numerous genetic variants associated with agronomic traits in cattle. However, such variants are often simply markers in linkage disequilibrium with the actual causal variants, which is a limiting factor for the development of accurate genomic predictions. It is possible to identify causal variants by integrating...

Read the complete abstract on PubMed

Topics

Animals
Cattle
Quantitative Trait Loci
RNA Splicing
Genome-Wide Association Study
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Linkage Disequilibrium

Genome

Genetic Variation

Deep Learning

Humans

Source

Open in PubMed Open full text

Identifiers

PMID: 40274775
DOI: 10.1038/s41467-025-58970-5
PMCID: PMC12022281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional impact of splicing variants in the elaboration of complex traits in cattle.PMID 40274775Read ↗

Genome variants associated with RNA splicing variations in bovine are extensively shared between tissues.Semantic proximity Read ↗

A multi-tissue atlas of regulatory variants in cattle.Semantic proximity Read ↗

Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traitsSemantic proximity Read ↗

Pangenome-genotyped structural variation improves molecular phenotype mapping in cattle.Semantic proximity Read ↗

Molecular QTL are enriched for structural variants in a cattle long-read cohort.Semantic proximity Read ↗

The enhanced multi-tissue atlas of regulatory effects in cattleSemantic proximity Read ↗

A novel reusable transcriptome-wide association study workflow used to map key genes linked to important cattle traits.Semantic proximity Read ↗

A high-resolution atlas of cattle regulatory variants and their cross-species activity in matched human cellsSemantic proximity Read ↗

Biobank-scale Bayesian TWAS reveals splicing-mediated mechanisms of complex diseaseSemantic proximity Read ↗

Structural variants and short tandem repeats impact gene expression and splicing in bovine testis tissue.Semantic proximity Read ↗

Bayesian genome-wide analysis of cattle traits using variants with functional and evolutionary significanceSemantic proximity Read ↗

Genome-wide fine-mapping identifies pleiotropic and functional variants that predict many traits across global cattle populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.