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Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study

29 Jul 2021

Abstract excerpt

BACKGROUND: Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index (FMI), fat-free mass index (FFMI), and height with cancer risk. METHODS AND FINDINGS: Single nucleotide polymorphisms (SNPs) were used as instrumental variables for BMI (312 SNPs), FMI (577...

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PMID: 34324486
DOI: 10.1371/journal.pmed.1003706

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