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The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy

7 Sept 2022

Abstract excerpt

As our understanding of the mechanisms of cancer treatment has increased, a growing number of studies demonstrate pathways through which DNA damage repair (DDR) affects the immune system. At the same time, the varied response of patients to immune checkpoint blockade (ICB) therapy has prompted the discovery of various predictive biomarkers and the study of combination therapy. Here, our investigation explores the...

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PMID: 36071479
DOI: 10.1186/s13046-022-02469-0

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