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Article

Impact of DNA damage response defects in cancer cells on response to immunotherapy and radiotherapy.

Journal of medical imaging and radiation oncology - 1 Jun 2022

Czajkowski Daniel, Szmyd Radosław, Gee Harriet E

Abstract excerpt

The DNA damage response (DDR) is a complex set of downstream pathways triggered in response to DNA damage to maintain genomic stability. Many tumours exhibit mutations which inactivate components of the DDR, making them prone to the accumulation of DNA defects. These can both facilitate the development of tumours and provide potential targets for novel therapeutic interventions. The inhibition of the DDR has been...

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Identifiers

PMID: 35460184
DOI: 10.1111/1754-9485.13413
PMCID: PMC9321602

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