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Article

DNA Repair Gene Mutations as Predictors of Immune Checkpoint Inhibitor Response beyond Tumor Mutation Burden.

Cell reports. Medicine - 23 Jun 2020

Hsiehchen David, Hsieh Antony, Samstein Robert M, Lu Tianshi, Beg Muhammad S, Gerber David E, Wang Tao, Morris Luc G T, Zhu Hao

Abstract excerpt

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, but prediction of their benefit is challenging. Neoantigens generated through impaired non-mismatch DNA repair may result in greater ICI activity. By analyzing 1,661 ICI-treated patients, we show that deletions and mutations in nucleotide excision repair (NER) and homologous repair (HR) pathways are predictors of ICI benefit independent of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32676589
DOI: 10.1016/j.xcrm.2020.100034
PMCID: PMC7365618

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