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Two decades of a protooncogene TBL1XR1: from a transcription modulator to cancer therapeutic target

28 Jan 2024

Abstract excerpt

Transducin beta-like 1X-related protein 1 (TBL1XR1) was discovered two decades ago and was implicated as part of the nuclear transcription corepressor complex. Over the past 20 years, the emerging oncogenic function of TBL1XR1 in cancer development has been discovered. Recent studies have highlighted that the genetic aberrations of TBL1XR1 in cancers, especially in hematologic tumors, are closely associated with...

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PMID: 38347836
DOI: 10.3389/fonc.2024.1309687

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