Article
A PilZ domain protein interacts with the transcriptional regulator HinK to regulate type VI secretion system in Pseudomonas aeruginosa.
The Journal of biological chemistry - 1 Mar 2024
Cheng Tianfang, Cheang Qing Wei, Xu Linghui, Sheng Shuo, Li Zhaoting, Shi Yu, Zhang Huiyan, Pang Li Mei, Liu Ding Xiang, Yang Liang, Liang Zhao-Xun, Wang Junxia
Abstract excerpt
Type VI secretion systems (T6SS) are bacterial macromolecular complexes that secrete effectors into target cells or the extracellular environment, leading to the demise of adjacent cells and providing a survival advantage. Although studies have shown that the T6SS in Pseudomonas aeruginosa is regulated by the Quorum Sensing system and second messenger c-di-GMP, the underlying molecular mechanism remains largely...
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