Article
TagR promotes PpkA-catalysed type VI secretion activation in Pseudomonas aeruginosa.
Molecular microbiology - 1 Jun 2009
Hsu FoSheng, Schwarz Sandra, Mougous Joseph D
Abstract excerpt
Type VI secretion systems (T6SSs) contribute to interactions of bacterial pathogens and symbionts with their hosts. Previously, we showed that Pseudomonas aeruginosa T6S is posttranslationally activated upon phosphorylation of Fha1, an FHA domain protein, by PpkA, a membrane-spanning threonine kinase. Herein, additional structural, enzymatic and genetic requirements for PpkA-catalysed T6SS activation are...
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