Article
Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa.
Nature cell biology - 1 Jul 2007
Mougous Joseph D, Gifford Casey A, Ramsdell Talia L, Mekalanos John J
Abstract excerpt
Secreted proteins are crucial to the arsenal of bacterial pathogens. Although optimal activity of these proteins is likely to require precise regulation of release, the signalling events that trigger secretion are poorly understood. Here, we identify a threonine phosphorylation event that post-translationally regulates the Hcp secretion island-I-encoded type VI secretion system of Pseudomonas aeruginosa (H-T6SS)....
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