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Article

FKBP5 DNA methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study.

Journal of psychiatric research - 1 Jan 2018

Bustamante Angela C, Aiello Allison E, Guffanti Guia, Galea Sandro, Wildman Derek E, Uddin Monica

Abstract excerpt

Exposure to childhood maltreatment increases the risk of developing mental illness later in life. Childhood maltreatment and depression have both been associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis-a key regulator of the body's stress response. Additionally, HPA axis dysregulation has been implicated in the etiology of a range of mental illnesses. A substantial body of work has...

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Source

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Identifiers

PMID: 28961425
DOI: 10.1016/j.jpsychires.2017.09.016
PMCID: PMC5698158

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FKBP5 DNA methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study.PMID 28961425Read ↗

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