Identifying genetic contributions of 6q21 loci and PPAR pathway to antipsychotic-induced metabolic syndrome: a Sex-Stratified Multi-Omics study.

doi:10.1038/s41380-026-03544-0

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Identifying genetic contributions of 6q21 loci and PPAR pathway to antipsychotic-induced metabolic syndrome: a Sex-Stratified Multi-Omics study.

Molecular psychiatry - 1 Jul 2026

Zhao Guorui, Sun Yaoyao, Lu Zhe, Kang Zhewei, Yu Tong, Zhang Yuyanan, Sun Junyuan, Guo Jing, Feng Xiaoyang, Yuan Rui, Zhu Yunqing, Yang Yang, Cui Mingrui, Yue Weihua

Abstract excerpt

Antipsychotics-induced metabolic syndrome (APs-induced MetS) is a common side-effect of antipsychotics, significantly increasing the risk of cardiovascular diseases and mortality. However, the genetic risk factors underlying APs-induced MetS remain poorly understood. Thus, we conducted a sex-stratified genome-wide association study (GWAS) in 3067 patients from Schizophrenia In Non-Occidental participants (SINO)...

Topics

Adult
Female
Humans
Male
Middle Aged
Antipsychotic Agents
Genetic Risk Score
Genome-Wide Association Study
Genotype
Metabolic Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multiomics

Peroxisome Proliferator-Activated Receptors

Polymorphism, Single Nucleotide

Proteomics

Risk Factors

Schizophrenia

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 41865124
DOI: 10.1038/s41380-026-03544-0

Genes

SNX3
AFG1L
NR2E1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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