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Centromeric AA motif in KIR as an optimal surrogate marker for precision definition of alloimmune reproductive failure

9 Feb 2024

Abstract excerpt

Throughout pregnancy, the decidua is predominantly populated by NK lymphocytes expressing Killer immunoglobulin-like receptors (KIR) that recognize human leukocyte antigen-C (HLA-C) ligands from trophoblast cells. This study aims to investigate the association of KIR-HLA-C phenotypes in couples facing infertility, particularly recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF), in comparison...

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PMID: 38336826
DOI: 10.1038/s41598-024-53766-x

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