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Article

ERAP/HLA-C and KIR Genetic Profile in Couples with Recurrent Implantation Failure.

International journal of molecular sciences - 19 Oct 2022

Piekarska Karolina, Radwan Paweł, Tarnowska Agnieszka, Radwan Michał, Wilczyński Jacek R, Malinowski Andrzej, Nowak Izabela

Abstract excerpt

Proper embryo implantation depends on the tolerance of the maternal immune system to the fetus and its foreign paternal antigens. During implantation and early pregnancy, the dominant leukocytes in the uterus are uterine NK cells, expressing killer immunoglobulin-like receptors (KIR). KIRs recognize human leukocyte antigens (HLA-C) on the human trophoblast inherited from the father and mother. The antigenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36293373
DOI: 10.3390/ijms232012518
PMCID: PMC9603896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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