Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human SPG11 cerebral organoids reveal cortical neurogenesis impairment

22 Nov 2018

Abstract excerpt

Spastic paraplegia gene 11(SPG11)-linked hereditary spastic paraplegia is a complex monogenic neurodegenerative disease that in addition to spastic paraplegia is characterized by childhood onset cognitive impairment, thin corpus callosum and enlarged ventricles. We have previously shown impaired proliferation of SPG11 neural progenitor cells (NPCs). For the delineation of potential defect in SPG11 brain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hereditary Neurological Disorders
Share to Hippo pathway signaling and YAP/TAZ
Share to Neurogenetic and Muscular Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30476097
DOI: 10.1093/hmg/ddy397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human SPG11 cerebral organoids reveal cortical neurogenesis impairmentPMID 30476097Read ↗

GSK3ß‐dependent dysregulation of neurodevelopment in SPG11‐patient induced pluripotent stem cell modelSemantic proximity Read ↗

Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like (ASPM related primary) microcephaly disease.Semantic proximity Read ↗

BRN2 and PTN unveil multiple neurodevelopmental mechanisms in Schizophrenia patient-derived cerebral organoidsSemantic proximity Read ↗

Hallmark molecular and pathological features of POLG disease are recapitulated in cerebral organoidsSemantic proximity Read ↗

SPG11 models reveal lysosomal calcium as a regulator of neural progenitor proliferationSemantic proximity Read ↗

Cerebral organoids to unravel the mechanisms underlying malformations of human cortical development.Semantic proximity Read ↗

SPG11 models reveal lysosomal calcium regulation of neural progenitor proliferation.Semantic proximity Read ↗

Robust Production of Uniform Human Cerebral Organoids from Pluripotent Stem CellsSemantic proximity Read ↗

Modeling spastic paraplegia 4 with corticospinal motor neuron-enriched cortical organoids reveals genotype-phenotype and HDAC6-targetable pathology.Semantic proximity Read ↗

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs).Semantic proximity Read ↗

Human brain organogenesis: Toward a cellular understanding of development and disease.Semantic proximity Read ↗

Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by ImmunostainingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.