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Article

Modulator of TMB-associated immune infiltration (MOTIF) predicts immunotherapy response and guides combination therapy.

Science bulletin - 30 Mar 2024

Qian Zheng-Yu, Pan Yi-Qian, Li Xue-Xin, Chen Yan-Xing, Wu Hao-Xiang, Liu Ze-Xian, Kosar Martin, Bartek Jiri, Wang Zi-Xian, Xu Rui-Hua

Abstract excerpt

Patients with high tumor mutational burden (TMB) levels do not consistently respond to immune checkpoint inhibitors (ICIs), possibly because a high TMB level does not necessarily result in adequate infiltration of CD8+ T cells. Using bulk ribonucleic acid sequencing (RNA-seq) data from 9311 tumor samples across 30 cancer types, we developed a novel tool called the modulator of TMB-associated immune infiltration...

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Source

Identifiers

PMID: 38320897
DOI: 10.1016/j.scib.2024.01.025

Genes

EMC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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