Article
Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy.
Cancer research - 15 May 2021
Frau Carla, Jamard Catherine, Delpouve Gaspard, Guardia Gabriela D A, Machon Christelle, Pilati Camilla, Nevé Clémentine Le, Laurent-Puig Pierre, Guitton Jérôme, Galante Pedro A F, Penalva Luiz O, Freund Jean-Noel, de la Fouchardiere Christelle, Plateroti Michelina
Abstract excerpt
Intestinal crypts are composed of heterogeneous and highly plastic cell populations. Lgr5high-stem cells (SC) are responsible for homeostatic renewal, but other cells can revert to an SC-like phenotype to maintain epithelial integrity. Despite their distinct roles in orchestrating homeostasis, both populations have been designated as the putative "cell-of-origin" of colorectal cancer. However, their respective...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.