Article

Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors

2018-05-02

Abstract excerpt

<h4>ABSTRACT</h4> Previously Aznar et al., showed that Daple enables Wnt/Frizzled receptors to transactivate trimeric G proteins during non-canonical Wnt signaling via a novel G-protein binding and activating (GBA) motif. By doing so, Daple serves as a double-edged sword; earlier during oncogenesis it suppresses neoplastic transformation and tumor growth, but later it triggers epithelial messenchymal transition (...

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Literature Corpus work: 223f63f4-c060-51de-b182-2cf744b87ae6
DOI: 10.1101/312934

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