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Molecular characterization of AIFM2/FSP1 inhibition by iFSP1-like molecules

21 Apr 2023

Abstract excerpt

Ferroptosis is a form of cell death characterized by phospholipid peroxidation, where numerous studies have suggested that the induction of ferroptosis is a therapeutic strategy to target therapy refractory cancer entities. Ferroptosis suppressor protein 1 (FSP1), an NAD(P)H-ubiquinone reductase, is a key determinant of ferroptosis vulnerability, and its pharmacological inhibition was shown to strongly sensitize...

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PMID: 37080964
DOI: 10.1038/s41419-023-05787-z

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