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One-pot DTECT enables rapid and efficient capture of genetic signatures for precision genome editing and clinical diagnostics.

Cell reports methods - 26 Feb 2024

Baudrier Lou, Benamozig Orléna, Langley Jethro, Chopra Sanchit, Kalashnikova Tatiana, Benaoudia Sacha, Singh Gurpreet, Mahoney Douglas J, Wright Nicola A M, Billon Pierre

Abstract excerpt

The detection of genomic sequences and their alterations is crucial for basic research and clinical diagnostics. However, current methodologies are costly and time-consuming and require outsourcing sample preparation, processing, and analysis to genomic companies. Here, we establish One-pot DTECT, a platform that expedites the detection of genetic signatures, only requiring a short incubation of a PCR product in...

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PMID: 38301655
DOI: 10.1016/j.crmeth.2024.100698
PMCID: PMC10921016

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