Article
Detection of Marker-Free Precision Genome Editing and Genetic Variation through the Capture of Genomic Signatures.
Cell reports - 10 Mar 2020
Billon Pierre, Nambiar Tarun S, Hayward Samuel B, Zafra Maria P, Schatoff Emma M, Oshima Koichi, Dunbar Andrew, Breinig Marco, Park Young C, Ryu Han S, Tschaharganeh Darjus F, Levine Ross L, Baer Richard, Ferrando Adolfo, Dow Lukas E, Ciccia Alberto
Abstract excerpt
Genome editing technologies have transformed our ability to engineer desired genomic changes within living systems. However, detecting precise genomic modifications often requires sophisticated, expensive, and time-consuming experimental approaches. Here, we describe DTECT (Dinucleotide signaTurE CapTure), a rapid and versatile detection method that relies on the capture of targeted dinucleotide signatures...
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