Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.

doi:10.1016/j.celrep.2016.12.061

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.

Cell reports - 17 Jan 2017

Momcilovic Milica, Bailey Sean T, Lee Jason T, Fishbein Michael C, Magyar Clara, Braas Daniel, Graeber Thomas, Jackson Nicholas J, Czernin Johannes, Emberley Ethan, Gross Matthew, Janes Julie, Mackinnon Andy, Pan Alison, Rodriguez Mirna, Works Melissa, Zhang Winter, Parlati Francesco, Demo Susan, Garon Edward, Krysan Kostyantyn, Walser Tonya C, Dubinett Steven M, Sadeghi Saman, Christofk Heather R, Shackelford David B

Abstract excerpt

Cancer cells exhibit increased use of nutrients, including glucose and glutamine, to support the bioenergetic and biosynthetic demands of proliferation. We tested the small-molecule inhibitor of glutaminase CB-839 in combination with erlotinib on epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) as a therapeutic strategy to simultaneously impair cancer glucose and glutamine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carbon Radioisotopes

Share to Erlotinib Hydrochloride

Share to Fluorodeoxyglucose F18

Share to Glutaminase

Share to Radiopharmaceuticals

Share to Thiadiazoles

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 28099841
DOI: 10.1016/j.celrep.2016.12.061
PMCID: PMC5260616

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.PMID 28099841Read ↗

Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer.Semantic proximity Read ↗

Role and therapeutic targeting of glutamine metabolism in non‑small cell lung cancer (Review)Semantic proximity Read ↗

Role of metabolic reprogramming in drug resistance to epidermal growth factor tyrosine kinase inhibitors in non-small cell lung cancer.Semantic proximity Read ↗

Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell LinesSemantic proximity Read ↗

Amino Acid and Glucose Fermentation Maintain ATP Content in Mouse and Human Malignant Glioma CellsSemantic proximity Read ↗

Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.Semantic proximity Read ↗

Genomic alterations and their correlation with metabolic-related genes in lung cancer.Semantic proximity Read ↗

NSCLC presents metabolic heterogeneity, and there is still some leeway for EGF stimuli in EGFR-mutated NSCLC.Semantic proximity Read ↗

Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibitionSemantic proximity Read ↗

The combined inhibition of SLC1A3 and glutaminase in osimertinib-resistant EGFR mutant cells.Semantic proximity Read ↗

Metabolic Signaling Cascades Prompted by Glutaminolysis in CancerSemantic proximity Read ↗

Heterogeneity of glutamine metabolism in acquired-EGFR-TKI-resistant lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.