Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prognostic impact of cooccurring mutations in FLT3-ITD pediatric acute myeloid leukemia.

Blood advances - 14 May 2024

Tarlock Katherine, Gerbing Robert B, Ries Rhonda E, Smith Jenny L, Leonti Amanda, Huang Benjamin J, Kirkey Danielle, Robinson Leila, Peplinski Jack H, Lange Beverly, Cooper Todd M, Gamis Alan S, Kolb E Anders, Aplenc Richard, Pollard Jessica A, Alonzo Todd A, Meshinchi Soheil

Abstract excerpt

ABSTRACT: We sought to define the cooccurring mutational profile of FLT3-ITD-positive (ITDpos) acute myeloid leukemia (AML) in pediatric and young adult patients and to define the prognostic impact of cooperating mutations. We identified 464 patients with FLT3-ITD mutations treated on Children's Oncology Group trials with available sequencing and outcome data. Overall survival, event-free survival (EFS), and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

Share to Infant

Share to Leukemia, Myeloid, Acute

Share to Nucleophosmin

Share to Prognosis

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 38295280
DOI: 10.1182/bloodadvances.2023011980
PMCID: PMC11063409

Genes

FLT3
EFS
NSD1
NUP98
NPM1
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic impact of cooccurring mutations in FLT3-ITD pediatric acute myeloid leukemia.PMID 38295280Read ↗

Frequency and impact of somatic co-occurring mutations on post-transplant outcomes in acute myeloid leukemia: a multicenter registry analysis on behalf of the EBMT ALWP.Semantic proximity Read ↗

Co-mutation landscape and its prognostic impact on newly diagnosed adult patients with NPM1-mutated de novo acute myeloid leukemiaSemantic proximity Read ↗

Frequency and Impact of Somatic Co-occurring Mutations on Post-Transplant Outcomes in Acute Myeloid Leukemia: A Multicenter Registry Analysis on Behalf of the EBMT ALWPSemantic proximity Read ↗

MutatedWT1,FLT3-ITD,andNUP98-NSD1Fusion in Various Combinations Define a Poor Prognostic Group in Pediatric Acute Myeloid LeukemiaSemantic proximity Read ↗

Uncovering the Genomic Landscape in Newly Diagnosed and Relapsed Pediatric Cytogenetically Normal FLT3‐ITD AMLSemantic proximity Read ↗

Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia.Semantic proximity Read ↗

Only FLT3-ITD co-mutation did not have a deleterious effect on acute myeloid leukemia patients with NPM1 mutation, but concomitant with DNMT3A co-mutation or a < 3log reduction of MRD2 predicted poor survival.Semantic proximity Read ↗

CEBPA-bZip mutations are associated with favorable prognosis in de novo AML: a report from the Children's Oncology Group.Semantic proximity Read ↗

Clinicogenetic characteristics and outcomes of children with NUP98-rearranged acute myeloid leukaemia: A single-centre cohort study of 32 cases.Semantic proximity Read ↗

Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study resultsSemantic proximity Read ↗

Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia - a HARMONY study.Semantic proximity Read ↗

NUP98 rearrangements in adult AML patients: Evaluation of clinical implications and identification of novel fusion partnersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.