Next-generation sequencing of cerebrospinal fluid for clinical molecular diagnostics in pediatric, adolescent and young adult brain tumor patients.

doi:10.1093/neuonc/noac035

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Article

Next-generation sequencing of cerebrospinal fluid for clinical molecular diagnostics in pediatric, adolescent and young adult brain tumor patients.

Neuro-oncology - 3 Oct 2022

Miller Alexandra M, Szalontay Luca, Bouvier Nancy, Hill Katherine, Ahmad Hamza, Rafailov Johnathan, Lee Alex J, Rodriguez-Sanchez M Irene, Yildirim Onur, Patel Arti, Bale Tejus A, Benhamida Jamal K, Benayed Ryma, Arcila Maria E, Donzelli Maria, Dunkel Ira J, Gilheeney Stephen W, Khakoo Yasmin, Kramer Kim, Sait Sameer F, Greenfield Jeffrey P, Souweidane Mark M, Haque Sofia, Mauguen Audrey, Berger Michael F, Mellinghoff Ingo K, Karajannis Matthias A

Abstract excerpt

BACKGROUND: Safe sampling of central nervous system tumor tissue for diagnostic purposes may be difficult if not impossible, especially in pediatric patients, and an unmet need exists to develop less invasive diagnostic tests. METHODS: We report our clinical experience with minimally invasive molecular diagnostics using a clinically validated assay for sequencing of cerebrospinal fluid (CSF) cell-free DNA...

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Identifiers

PMID: 35148412
DOI: 10.1093/neuonc/noac035
PMCID: PMC9527510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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