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Article

Exploring the role of sporadic BRAF and KRAS mutations during colorectal cancer pathogenesis: A spotlight on the contribution of the endosome-lysosome system.

Cancer letters - 31 Mar 2024

Tang Jingying, Lam Giang T, Brooks Robert D, Miles Mark, Useckaite Zivile, Johnson Ian Rd, Ung Ben S-Y, Martini Carmela, Karageorgos Litsa, Hickey Shane M, Selemidis Stavros, Hopkins Ashley M, Rowland Andrew, Vather Ryash, O'Leary John J, Brooks Douglas A, Caruso Maria C, Logan Jessica M

Abstract excerpt

The highly heterogenous nature of colorectal cancer can significantly hinder its early and accurate diagnosis, eventually contributing to high mortality rates. The adenoma-carcinoma sequence and serrated polyp-carcinoma sequence are the two most common sequences in sporadic colorectal cancer. Genetic alterations in adenomatous polyposis coli (APC), v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and...

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Identifiers

PMID: 38290660
DOI: 10.1016/j.canlet.2024.216639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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