Article
Proteogenomic and metabolomic characterization of human glioblastoma.
Cancer cell - 12 Apr 2021
Wang Liang-Bo, Karpova Alla, Gritsenko Marina A, Kyle Jennifer E, Cao Song, Li Yize, Rykunov Dmitry, Colaprico Antonio, Rothstein Joseph H, Hong Runyu, Stathias Vasileios, Cornwell MacIntosh, Petralia Francesca, Wu Yige, Reva Boris, Krug Karsten, Pugliese Pietro, Kawaler Emily, Olsen Lindsey K, Liang Wen-Wei, Song Xiaoyu, Dou Yongchao, Wendl Michael C, Caravan Wagma, Liu Wenke, Cui Zhou Daniel, Ji Jiayi, Tsai Chia-Feng, Petyuk Vladislav A, Moon Jamie, Ma Weiping, Chu Rosalie K, Weitz Karl K, Moore Ronald J, Monroe Matthew E, Zhao Rui, Yang Xiaolu, Yoo Seungyeul, Krek Azra, Demopoulos Alexis, Zhu Houxiang, Wyczalkowski Matthew A, McMichael Joshua F, Henderson Brittany L, Lindgren Caleb M, Boekweg Hannah, Lu Shuangjia, Baral Jessika, Yao Lijun, Stratton Kelly G, Bramer Lisa M, Zink Erika, Couvillion Sneha P, Bloodsworth Kent J, Satpathy Shankha, Sieh Weiva, Boca Simina M, Schürer Stephan, Chen Feng, Wiznerowicz Maciej, Ketchum Karen A, Boja Emily S, Kinsinger Christopher R, Robles Ana I, Hiltke Tara, Thiagarajan Mathangi, Nesvizhskii Alexey I, Zhang Bing, Mani D R, Ceccarelli Michele, Chen Xi S, Cottingham Sandra L, Li Qing Kay, Kim Albert H, Fenyö David, Ruggles Kelly V, Rodriguez Henry, Mesri Mehdi, Payne Samuel H, Resnick Adam C, Wang Pei, Smith Richard D, Iavarone Antonio, Chheda Milan G, Barnholtz-Sloan Jill S, Rodland Karin D, Liu Tao, Ding Li
Abstract excerpt
Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its molecular pathogenesis is crucial to improving diagnosis and treatment. Integrated analysis of genomic, proteomic, post-translational modification and metabolomic data on 99 treatment-naive GBMs provides insights to GBM biology. We identify key phosphorylation events (e.g., phosphorylated PTPN11 and PLCG1) as potential switches...
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