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ERCC1 abundance is an indicator of DNA repair-apoptosis decision upon DNA damage

25 Jan 2024

Abstract excerpt

DNA repair is essential for successful propagation of genetic material and fidelity of transcription. Nucleotide excision repair (NER) is one of the earliest DNA repair mechanisms, functionally conserved from bacteria to human. The fact that number of NER genes vary significantly between prokaryotes and metazoans gives the insight that NER proteins have evolved to acquire additional functions to combat challenges...

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PMID: 38272916
DOI: 10.1038/s41420-024-01817-7

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