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Article

DNA repair pathways and cisplatin resistance: an intimate relationship

1 Jan 2018

Abstract excerpt

The main goal of chemotherapeutic drugs is to induce massive cell death in tumors. Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its remarkable efficiency, most tumors show intrinsic or acquired drug resistance. The primary biological target of cisplatin is genomic DNA, and it causes a plethora of DNA lesions that block transcription and replication. These cisplatin-induced...

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PMID: 30208165
DOI: 10.6061/clinics/2018/e478s

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