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Article

Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma

1 Jun 2022

Abstract excerpt

To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into retinal organoids and compared with those from healthy individuals. We performed single-cell RNA sequencing of a total of 247,520 cells and identified cluster-specific molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36778138
DOI: 10.1016/j.xgen.2022.100142

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