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Imputation Server PGS: an automated approach to calculate polygenic risk scores on imputation servers.

Nucleic acids research - 5 Jul 2024

Forer Lukas, Taliun Daniel, LeFaive Jonathon, Smith Albert V, Boughton Andrew P, Coassin Stefan, Lamina Claudia, Kronenberg Florian, Fuchsberger Christian, Schönherr Sebastian

Abstract excerpt

Polygenic scores (PGS) enable the prediction of genetic predisposition for a wide range of traits and diseases by calculating the weighted sum of allele dosages for genetic variants associated with the trait or disease in question. Present approaches for calculating PGS from genotypes are often inefficient and labor-intensive, limiting transferability into clinical applications. Here, we present 'Imputation...

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PMID: 38709879
DOI: 10.1093/nar/gkae331
PMCID: PMC11223871

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