NfL reliability across laboratories, stage-dependent diagnostic performance and matrix comparability in genetic FTD: a large GENFI study.

doi:10.1136/jnnp-2023-332464

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Article

NfL reliability across laboratories, stage-dependent diagnostic performance and matrix comparability in genetic FTD: a large GENFI study.

Journal of neurology, neurosurgery, and psychiatry - 16 Aug 2024

Linnemann Christoph, Wilke Carlo, Mengel David, Zetterberg Henrik, Heller Carolin, Kuhle Jens, Bouzigues Arabella, Russell Lucy L, Foster Phoebe H, Ferry-Bolder Eve, Van Swieten John Cornelis, Jiskoot Lize C, Seelaar Harro, Moreno Fermin, Borroni Barbara, Sánchez-Valle Raquel, Galimberti Daniela, Laforce Robert, Graff Caroline, Masellis Mario, Tartaglia Maria Carmela, Rowe James Benedict, Finger Elizabeth, Vandenberghe Rik, de Mendonca Alexandre, Butler Chris R, Gerhard Alexander, Ducharme Simon, Ber Isabelle L E, Tiraboschi Pietro, Santana Isabel, Pasquier Florence, Levin Johannes, Otto Markus, Sorbi Sandro, Rohrer Jonathan Daniel, Synofzik Matthis

Abstract excerpt

BACKGROUND: Blood neurofilament light chain (NfL) is increasingly considered as a key trial biomarker in genetic frontotemporal dementia (gFTD). We aimed to facilitate the use of NfL in gFTD multicentre trials by testing its (1) reliability across labs; (2) reliability to stratify gFTD disease stages; (3) comparability between blood matrices and (4) stability across recruiting sites. METHODS: Comparative analysis...

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PMID: 38253362
DOI: 10.1136/jnnp-2023-332464
PMCID: PMC11347244

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