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Article

Serum neurofilament light chain as a surrogate of cognitive decline in sporadic and familial frontotemporal dementia

10 Aug 2021

Abstract excerpt

BACKGROUND AND PURPOSE: Neurofilament light chain (NfL) has recently been proposed as a promising biomarker in frontotemporal dementia (FTD). We investigated the correlation of both cerebrospinal fluid (CSF) and serum NfL with detailed neuropsychological data and cognitive decline in a cohort of sporadic and familial FTD. METHODS: CSF and serum NfL, as well as conventional CSF Alzheimer's disease (AD) biomarkers...

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PMID: 34375485
DOI: 10.1111/ene.15058

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