Article
Clinical and Genomic Predictors of Adverse Events in Newly Diagnosed Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2024
Lim-Fat Mary Jane, Iorgulescu J Bryan, Rahman Rifaquat, Bhave Varun, Muzikansky Alona, Woodward Eleanor, Whorral Sydney, Allen Marie, Touat Mehdi, Li Xiaomei, Xy Gongwen, Patel Jay, Gerstner Elizabeth R, Kalpathy-Cramer Jayashree, Youssef Gilbert, Chukwueke Ugonma, McFaline-Figueroa J Ricardo, Nayak Lakshmi, Lee Eudocia Q, Reardon David A, Beroukhim Rameen, Huang Raymond Y, Bi Wenya Linda, Ligon Keith L, Wen Patrick Y
Abstract excerpt
PURPOSE: Adverse clinical events cause significant morbidity in patients with GBM (GBM). We examined whether genomic alterations were associated with AE (AE) in patients with GBM. EXPERIMENTAL DESIGN: We identified adults with histologically confirmed IDH-wild-type GBM with targeted next-generation sequencing (OncoPanel) at Dana Farber Cancer Institute from 2013 to 2019. Seizure at presentation, lymphopenia,...
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