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Article

Divisional history and hematopoietic stem cell function during homeostasis.

Stem cell reports - 8 Apr 2014

Qiu Jiajing, Papatsenko Dmitri, Niu Xiaohong, Schaniel Christoph, Moore Kateri

Abstract excerpt

We investigated the homeostatic behavior of hematopoietic stem and progenitor cells (HSPCs) temporally defined according to their divisional histories using an HSPC-specific GFP label-retaining system. We show that homeostatic hematopoietic stem cells (HSCs) lose repopulating potential after limited cell divisions. Once HSCs exit dormancy and accrue divisions, they also progressively lose the ability to return to...

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Identifiers

PMID: 24749072
DOI: 10.1016/j.stemcr.2014.01.016
PMCID: PMC3986626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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