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Novel insight into histological and molecular astrocytoma, IDH-mutant, Grade 4 by the updated WHO classification of central nervous system tumors.

Cancer medicine - 1 Sept 2023

Chen Wenlin, Guo Siying, Wang Yaning, Shi Yixin, Guo Xiaopeng, Liu Delin, Li Yilin, Wang Yuekun, Xing Hao, Xia Yu, Li Junlin, Wu Jiaming, Liang Tingyu, Wang Hai, Liu Qianshu, Jin Shanmu, Qu Tian, Li Huanzhang, Yang Tianrui, Zhang Kun, Wang Yu, Ma Wenbin

Abstract excerpt

BACKGROUND: The latest fifth edition of the World Health Organization (WHO) classification of the central nervous system (CNS) tumors (WHO CNS 5 classification) released in 2021 defined astrocytoma, IDH-mutant, Grade 4. However, the understanding of this subtype is still limited. We conducted this study to describe the features of astrocytoma, IDH-mutant, Grade 4 and explored the similarities and differences...

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PMID: 37667984
DOI: 10.1002/cam4.6476
PMCID: PMC10557904

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