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Article

Expanding the molecular grading criteria in IDH-mutant astrocytoma.

Neuro-oncology - 1 Aug 2026

Virata Michael Christian, Samanamud Jorge, Slocum Cheyanne C, Kandoi Shrishtee, Nguyen Phuong, Savani Milan R, Shi Diana D, Sharma Sachein, Hiya Satomi, Maldonado-Díaz Carolina, Clare Kevin, Yokoda Raquel T, Vij Meenakshi, Mir Ema, Nishikawa Yurika, Umphlett Melissa, Yong Raymund L, Bederson Joshua B, Silva-Hurtado Thenzing J, Brem Steven, Hambardzumyan Dolores, Snuderl Matija, Viapiano Mariano S, Abdullah Kalil G, McBrayer Samuel K, Hatanpaa Kimmo J, Walker Jamie M, Tsankova Nadejda M, Richardson Timothy E

Abstract excerpt

BACKGROUND: IDH-mutant astrocytomas are classified as WHO grade 4 in the presence of conventional high-grade histologic features and/or homozygous CDKN2A/B deletion in the 5th edition of the WHO Classification of Central Nervous System Tumour guidelines. However, work over the past decade has indicated a number of other molecular alterations that warrant consideration as potential prognostic markers. METHODS: We...

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Identifiers

PMID: 41903203
DOI: 10.1093/neuonc/noag069
PMCID: PMC13437890

Genes

CCND2
CDK4
CDKN2A
EGFR
MYCN
PDGFRA
PIK3CA
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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