Article
A new strategy for systematically classifying HLA alleles into serological specificities: Update and refinement.
HLA - 1 Oct 2024
Osoegawa Kazutoyo, Yim Kenneth, Jeracki Megan, Nguyen Tuan-Nghia, Wang Lin, Cho Andrew, David Rhidina, Son Jellina, Mankey Arianne, Marsh Steven G E, Gendzekhadze Ketevan, Murphey Cathi, Fernández Viňa Marcelo A
Abstract excerpt
HLA antigens were historically defined according to the unique reactivity pattern of cells expressing HLA molecules with distinctive clusters of allo-antisera and/or monoclonal antibodies. Subsequently, amino acid residues determining epitopes (DEP) in the HLA molecule were correlated with reactivity patterns. In current clinical practice, the presence of allo-antibodies is assessed using Luminex-based solid...
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