Article
Antibody verification of HLA class I and class II eplets by human monoclonal HLA antibodies.
HLA - 1 Jan 2024
Kramer Cynthia S M, Bezstarosti Suzanne, Franke-van Dijk Marry E I, Vergunst Manon, Roelen Dave L, Uyar-Mercankaya Merve, Voogt-Bakker Kim H, Heidt Sebastiaan
Abstract excerpt
In solid organ transplantation, formation of de novo donor-specific HLA antibodies is induced by mismatched eplets on donor HLA molecules. While several studies have shown a strong correlation between the number of eplet mismatches and inferior outcomes, not every eplet mismatch is immunogenic. Eplets are theoretically defined entities, necessitating formal proof that they can be recognised and bound by...
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