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Association of Lipoprotein(a) with arterial stiffness: A Mendelian randomization study

18 Jan 2024

Abstract excerpt

BACKGROUND: In this study we used Mendelian randomization (MR) to investigate the potential causal association of lipoprotein (a) [Lp(a)] levels with pulse wave velocity (PWV). METHODS: Genetic variants associated with Lp(a) were retrieved from the UK Biobank GWAS (N = 290,497). A non- overlapping GWAS based on a European cohort (N = 7,000) was used to obtain genetic associations with PWV (outcome) and utilized...

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PMID: 38239089
DOI: 10.1111/eci.14168

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