Article
Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants.
BMC medicine - 13 Jun 2022
Borges Maria Carolina, Haycock Philip C, Zheng Jie, Hemani Gibran, Holmes Michael V, Davey Smith George, Hingorani Aroon D, Lawlor Deborah A
Abstract excerpt
BACKGROUND: Despite early interest in the health effects of polyunsaturated fatty acids (PUFA), there is still substantial controversy and uncertainty on the evidence linking PUFA to cardiovascular diseases (CVDs). We investigated the effect of plasma concentration of omega-3 PUFA (i.e. docosahexaenoic acid (DHA) and total omega-3 PUFA) and omega-6 PUFA (i.e. linoleic acid and total omega-6 PUFA) on the risk of...
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