Article
APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2016
Olabisi Opeyemi A, Zhang Jia-Yue, VerPlank Lynn, Zahler Nathan, DiBartolo Salvatore, Heneghan John F, Schlöndorff Johannes S, Suh Jung Hee, Yan Paul, Alper Seth L, Friedman David J, Pollak Martin R
Abstract excerpt
Two specific genetic variants of the apolipoprotein L1 (APOL1) gene are responsible for the high rate of kidney disease in people of recent African ancestry. Expression in cultured cells of these APOL1 risk variants, commonly referred to as G1 and G2, results in significant cytotoxicity. The underlying mechanism of this cytotoxicity is poorly understood. We hypothesized that this cytotoxicity is mediated by APOL1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.