Article
Offspring's own serotonin transporter genotype, independently from the maternal one, increases anxiety- and depression-like behavior and alters neuroplasticity markers in rats.
Journal of affective disorders - 1 Apr 2024
Sun Menghan, Brivio Paola, Shan Ling, Docq Sylvia, Heltzel Lisa C M W, Smits Celine A J, Middelman Anthonieke, Vrooman Roel, Spoelder Marcia, Verheij Michel M M, Buitelaar Jan K, Boillot Morgane, Calabrese Francesca, Homberg Judith R, Hanswijk Sabrina I
Abstract excerpt
INTRODUCTION: Developmental changes due to early life variations in the serotonin system affect stress-related behavior and neuroplasticity in adulthood. These outcomes can be caused both by offspring's own and maternal serotonergic genotype. We aimed to dissociate the contribution of the own genotype from the influences of mother genotype. METHODS: Sixty-six male homozygous (5-HTT-/-) and heterozygous (5-HTT+/-)...
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