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Article

Single-cell genomics analysis reveals complex genetic interactions in an in vivo model of acquired BRAF inhibitor resistance.

NAR cancer - 1 Mar 2024

Schillo Jacob L, Feddersen Charlotte R, Peplinski Rebekah M, Powell Lexy S, Varzavand Afshin, Stipp Christopher S, Riordan Jesse D, Dupuy Adam J

Abstract excerpt

The evolution of therapeutic resistance is a major obstacle to the success of targeted oncology drugs. While both inter- and intratumoral heterogeneity limit our ability to detect resistant subpopulations that pre-exist or emerge during treatment, our ability to analyze tumors with single-cell resolution is limited. Here, we utilized a cell-based transposon mutagenesis method to identify mechanisms of BRAF...

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Share to DNA Transposable Elements
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins B-raf

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Source

Open in PubMed Open full text

Identifiers

PMID: 38213996
DOI: 10.1093/narcan/zcad061
PMCID: PMC10782916

Genes

BRAF
NEDD4L
VGLL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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