Article

Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events

2024-11-21

Abstract excerpt

<title>Abstract</title> <p>Genotype-informed anticancer therapies such as BRAF inhibitors can show remarkable clinical efficacy in BRAF-mutant melanoma; however, drug resistance poses a major hurdle to successful cancer treatment. Many resistance events to targeted therapies have been identified, suggesting a complex path to improve therapeutics. Here, we showed the utility of a<italic> piggyBac</italic> transpos...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bdfb4ec5-6d60-57e0-ae92-ebcb96b211e4
DOI: 10.21203/rs.3.rs-5320870/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation eventsDOI 10.21203/rs.3.rs-5320870/v1Read

Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.Semantic proximity Read

BRAF inhibitor resistance in melanoma: from resistance mechanisms to therapeutic innovations.Semantic proximity Read

Single-cell genomics analysis reveals complex genetic interactions in an in vivo model of acquired BRAF inhibitor resistance.Semantic proximity Read

CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma.Semantic proximity Read

Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547.Semantic proximity Read

CRISPR Screens Identify Essential Cell Growth Mediators in BRAF-inhibitor Resistant MelanomaSemantic proximity Read

BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma modelSemantic proximity Read

A genome-wide net to catch and understand cancer.Semantic proximity Read

Same mutation, different fates: The Yin-Yang of BRAF-driven therapeutic responses in melanoma and colorectal cancer.Semantic proximity Read

Dissecting Mechanisms of Melanoma Resistance to BRAF and MEK Inhibitors Revealed Genetic and Non-Genetic Patient- and Drug-Specific Alterations and Remarkable Phenotypic PlasticitySemantic proximity Read

Resistance mechanisms to targeted therapy in BRAF-mutant melanoma - A mini review.Semantic proximity Read

Molecular pathways: mitogen-activated protein kinase pathway mutations and drug resistance.Semantic proximity Read