Article
GRIM-19 deficiency promotes macrophage polarization to the M1 phenotype partly through glycolysis in unexplained recurrent spontaneous abortion†.
Biology of reproduction - 11 Apr 2024
Wang Bingyu, Yang Yang, Ye Jinwen, Han Xiaojuan, Yang Lin, Huang Yufei, Chao Lan
Abstract excerpt
The occurrence of unexplained recurrent spontaneous abortion (URSA) is closely related to immune system disorders, however, the underlying mechanisms remain unclear. The purpose of this study was to investigate the expression of GRIM-19 in URSA and the possible pathogenesis of URSA according to macrophage polarization. Here, we showed that GRIM-19 was downregulated in the uterine decidual macrophages of patients...
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