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Article

Glucose-6-phosphate transporter mediates macrophage proliferation and functions by regulating glycolysis and mitochondrial respiration.

Biochemical and biophysical research communications - 26 Mar 2020

Jeon Eek Hyung, Park Tae Sub, Jang Yuyeon, Hwang Eunmi, Kim Sung-Jo, Song Ki-Duk, Weinstein David A, Lee Young Mok, Park Byung-Chul, Jun Hyun Sik

Abstract excerpt

Glycogen storage disease type Ib (GSD-Ib), caused by a deficiency in glucose-6-phosphate transporter (G6PT), is characterized by disrupted glucose homeostasis, inflammatory bowel disease, neutropenia, and neutrophil dysfunction. The purpose of this study was to investigate the role of G6PT on macrophage functions and metabolism. Peritoneal macrophages of G6pt-/- mice were lower in number and their effector...

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PMID: 31980167
DOI: 10.1016/j.bbrc.2020.01.043

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