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Celastrol induces premature ovarian insufficiency by inducing apoptosis in granulosa cells

11 Nov 2023

Abstract excerpt

Celastrol, a natural compound purified from the Chinese herb Tripterygium wilfordii Hook. f., has excellent pharmacological activity for the treatment of various diseases. Assessing the safety of its use is essential for its development into a clinical medicine. However, research assessing its toxicity on the female reproductive system has never been reported. In this study, the ovarian toxicity of celastrol and...

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PMID: 37956480
DOI: 10.1016/j.biopha.2023.115815

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